NRG and TerThera sign irradiation agreement to ensure the continuous supply of Terbium-161

NRG and TerThera sign irradiation agreement to ensure the continuous supply of Terbium-161

13 April 2023

PETTEN & BREDA, The Netherlands, 20th March 2023 - NRG and TerThera signed an agreement for irradiation services in the High Flux Reactor in Petten, the Netherlands to produce Terbium-161. The non-carrier-added (NCA) Terbium-161 is produced by neutron irradiation of highly enriched Gadolinium-160 targets in the Dutch research reactor. 

Terbium-161 is a promising novel radionuclide for cancer treatment, that can meet the growing demand in cancer healthcare, exhibiting comparable (radio)chemical characteristics to known radiolanthanides. Early research suggests however that as much as 16-fold increase in Auger and conversion electrons are emitted by Terbium-161 resulting in improved anti-tumor capabilities for primary and (micro)metastasized cancers. The first case report, published in February 2023, observing the increased therapeutic value of disseminated metastatic disease using Terbium-161 PSMA for Radioligand Therapy (RLT) after a single cycle provided early confirmation of Terbium-161’s potential.

The first batches have been successfully irradiated, delivered to TerThera’s production location for processing into the final product, and distributed globally to support preclinical and clinical initiatives. Thanks to the irradiation agreement, the two companies will work together to ensure a reliable and uninterrupted supply of Terbium-161 in support of cancer healthcare around the world.


“This irradiation agreement assures reliable access to Terbium-161 on a global level. In times of scarce availability of therapeutic radionuclides, TerThera will bring its product to GMP quality before the end of 2023 to broaden the access for clients all around the world.” - Philippe van Overeem, CEO of TerThera

Vial Terbium-161

About NRG

NRG is the operator of the High Flux Reactor (HFR) in Petten, the Netherlands. The company is one of the world’s largest manufacturers of radioisotopes for medical applications. Some 30,000 patients per day benefit from the products NRG creates in Petten.

About TerThera

Founded in 2021, TerThera strives to meet the growing global demand for radionuclides in cancer healthcare by providing a highly sustainable and uninterrupted supply of Terbium-161 for use in radioligand therapy.

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