CISSPECT DESK-LAB represents a great leap forward for the development of radiopharmaceuticals and personalised drug discovery. Recently, we have developed the world’s first fully automated synthesis module, CISSPECT DESK-LAB, for the synthesis of Pt-195m cisplatin and other platinum compounds
The module has been designed for the production of GMP Pt-195m Cisplatin to facilitate a human pilot study. We have achieved this in close collaboration with our industrial partner FutureChemistry and renowned Dutch Academic Medical Centres.
In addition to the Dhara synthesis according to Hoeschele et. al., Radiochimica Acta 1982
FutureChemistry Holding B.V. develops, builds and implements equipment and processes for manufacturing of chemicals with a high added value. With a focus in particular on two product groups: nanomaterials and radiopharmaceuticals.
“A great leap forward for the development of radiopharmaceuticals and personalised drug discovery.“
The main draw backs of cisplatin chemotherapy treatment is kidney toxicity, as well as the low response rate in many cases, which cannot be predicted beforehand. Pt-195m cisplatin, or CISSPECT, is developed to enable quantification of the in vivo bio distribution of cisplatin, a standard chemotherapeutic agent. Pt-195m cisplatin may be able to select patients who will not respond to cisplatin chemotherapy, or those patients who will suffer from severe kidney toxicity due to cisplatin treatment.
The feasibility of SPECT imaging and quantification of Pt-195m in a preclinical setting has already been shown (E.A. Aalbersberg et al., EJNMMI 2017 (44), 8, 1347 – 1354). As a next step, the feasibility in humans will be assessed. If successful, Pt-195m cisplatin contributes to optimising treatment outcome of chemo(radio)therapy and reducing toxicity in a personalised approach.